Dépression. S-adénosylméthionine (SAMe) partie 1
SAMe Stimule l'humeur, complète les antidépresseurs sur ordonnance
La dépression est un problème de santé publique majeur qui affecte les adolescents, les enfants et les adultes. Des générations successives d'antidépresseurs, tels que les antidépresseurs tricycliques et les inhibiteurs de la recapture de la sérotonine (ISRS), ont été saluées comme une avancée décisive dans le traitement de la dépression.
Les antidépresseurs tricycliques (tels que l'imipramine, l'amitryptiline, etc.) sont tombés en disgrâce au début des années 90, après avoir été de plus en plus connus, ils ont induit de nombreux effets secondaires graves et ont souvent été mal tolérés.8Ces effets secondaires semblaient être absents dans les nouveaux ISRS qui sont devenus extrêmement populaires dans les années 1990 et le restent aujourd'hui. Cependant, des découvertes récentes indiquant que les ISRS semblent augmenter le risque d'idées suicidaires chez certains patients ont été à la fois source de préoccupation et de controverse9. En 2004, la FDA a placé un avertissement «boîte noire» sur les ISRS, indiquant que les médicaments pourraient augmenter le risque de pensées suicidaires chez les enfants 10, et l’agence a continué de prévenir des effets secondaires possibles chez les patients de tous âges. Ces développements posent un dilemme épineux aux patients et à leurs médecins, qui souhaitent gérer avec succès la dépression tout en évitant les effets secondaires potentiellement fatals associés aux antidépresseurs sur ordonnance. Pour gérer efficacement et en toute sécurité la dépression, davantage de personnes se tournent vers SAMe. Bien que la SAMe ait été utilisée pour traiter la dépression pendant plus d'un quart de siècle 11,12, elle a fait l'objet de relativement peu d'attention dans la littérature médicale traditionnelle jusqu'à récemment. Aujourd'hui, cependant, de plus en plus de preuves suggèrent que SAMe fonctionne aussi bien que certains antidépresseurs, tout en démontrant un profil d'innocuité supérieur.
- Utilisée depuis longtemps en Europe comme médicament sur ordonnance pour lutter contre la dépression, la S-adénosylméthionine (SAMe) a été introduite aux États-Unis en 1996 par la Life Extension Foundation.
- SAMe participe à de nombreuses réactions biochimiques essentielles dans le corps, contribuant à la protection des antioxydants, à la signalisation cellulaire et à la production de neurotransmetteurs et d'hormones.
- SAMe élève rapidement et efficacement l'humeur dépressive, avec une efficacité comparable à celle des médicaments sur ordonnance et des effets secondaires minimes ou nuls. Cela peut même aider à gérer les cas de dépression résistante.
- La SAMe offre de nombreux avantages aux personnes atteintes de maladies du foie et de la vésicule biliaire en améliorant la circulation de la bile et en protégeant le foie contre les dommages induits par les toxines. Il soulage également la douleur et l'inflammation de l'arthrite, avec des effets comparables à ceux des médicaments anti-inflammatoires non stéroïdiens (AINS) tels que l'ibuprofène.
- SAMe favorise la santé de la fonction endothéliale et peut un jour être utilisé pour protéger les membranes des vaisseaux sanguins contre les dangereux effets de l'ischémie (manque d'oxygène) qui se produit lors d'une crise cardiaque, d'un accident vasculaire cérébral ou d'une greffe.
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