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Pourquoi tant de personnes souffrant d'arthrite ne parviennent pas à trouver un soulagement

8853 Vues Posté sur: 2016-03-17
Posté par: Ireneusz Adamczyk

Pourquoi tant de personnes souffrant d'arthrite ne parviennent pas à trouver un soulagementNotre société a été programmée pour croire que des problèmes médicaux complexes peuvent être résolus avec des solutions simples.

Tous les lecteurs de cet article ont probablement vu des milliers de publicités télévisées faisant la promotion du soulagement immédiat des douleurs arthritiques en prenant la bonne marque d'aspirine, l'ibuprofène, l'acétaminophène ou le naproxène.

Si un arthritique prend régulièrement l'un de ces analgésiques (à des doses approuvées par la FDA), il risque de subir des effets indésirables représentant un danger de mort, tels qu'une insuffisance rénale, une insuffisance hépatique ou une hémorragie gastrique.1-8

En revanche, les approches naturelles, telles que l'huile de poisson et la curcumine, apportent de nombreux avantages permettant de sauver des vies, en plus de soulager l'inconfort chronique des articulations9-40.

L'industrie pharmaceutique s'est concentrée sur le développement d'une seule intervention médicamenteuse à la fois pour traiter une cause sous-jacente de l'arthrite. Non seulement cette stratégie n’a pas permis de traiter les nombreux facteurs liés à l’âge impliqués dans l’arthrose, mais elle a également entraîné des déséquilibres métaboliques mortels dans le corps.

Lors de la première approbation de médicaments inhibiteurs de la COX-2 tels que Vioxx® et Bextra®, Life Extension® a averti qu'en bloquant uniquement l'enzyme COX-2 (et non les COX-1 et 5-LOX), les utilisateurs de ces médicaments augmentaient leur risque. de crise cardiaque et accident vasculaire cérébral. Alors que la plupart de nos membres ont été épargnés par ces effets secondaires mortels, des dizaines de milliers d'Américains ont péri avant que ces inhibiteurs de la COX-2 ne soient retirés41.

Ce que personne n’a fait jusqu’à présent, c’est de fusionner toutes les causes sous-jacentes connues de l’arthrite afin que les profanes et les médecins puissent comprendre pourquoi un soulagement à long terme nécessite une approche multidimensionnelle.

La bonne nouvelle pour les membres de Life Extension® est qu’ils utilisent déjà de nombreux moyens naturels pour améliorer la structure et les fonctions articulaires qui offrent un répit considérable en cas de gêne articulaire. Les deux pages suivantes donnent un aperçu des douze mécanismes sous-jacents impliqués dans l'arthrose et des méthodes sûres pour les contourner.

Douze causes corrigibles d'arthrose

Douze causes corrigibles d'arthroseComme beaucoup de maladies liées au vieillissement, l’arthrite n’est normalement pas causée par un seul facteur. Au lieu de cela, de multiples mécanismes conspirent pour détruire lentement le cartilage qui tapisse nos articulations. L'illustration ci-dessous révèle les causes sous-jacentes de l'arthrite et des mesures simples pour les contrecarrer.

L'excès de poids peut conduire à l'arthrite. Cela se produit non seulement parce que des charges mécaniques plus lourdes génèrent une plus grande contrainte physique sur les surfaces des tissus conjonctifs et des articulations, mais aussi par l'effet de l'excès de graisse sur l'augmentation du nombre de molécules inflammatoires qui attaquent et endommagent le cartilage articulaire. La perte de poids est un moyen efficace de se protéger contre le stress excessif aux articulations pouvant contribuer à l'arthrite42-26.

Un traumatisme physique important peut endommager les articulations. Bien que les avantages de l'exercice ne puissent être minimisés, des exercices répétitifs, tels que la course, à fort impact, peuvent exposer les articulations (particulièrement au niveau de la hanche et du genou) à des charges mécaniques élevées pouvant à terme les endommager. Faire de l'exercice qui renforce la force et la souplesse musculaires sans traumatisme articulaire répétitif peut réduire les complications de l'arthrite47-49.

La prostaglandine E2 provoque des douleurs et une inflammation des articulations. L’enzyme qui convertit l’acide arachidonique en prostaglandine E2 dans l’organisme est appelée COX-2 (cyclooxygénase-2).50 Les médicaments qui inhibent uniquement la COX-2 (comme Vioxx® et Bextra®) augmentent le risque de crises cardiaques car ils ont des effets néfastes sur les enzymes critiques des cellules endothéliales vasculaires qui tapissent la paroi des vaisseaux sanguins.51 Des moyens sûrs d'inhiber la COX-2 et la production ultérieure de prostaglandine E2 doivent être suivis d'un régime alimentaire pauvre en acide arachidonique, prendre un comprimé d'aspirine à faible dose (81 mg) chaque jour, et complétez avec des nutriments comme le resvératrol, l'extrait de thé vert, la silymarine et la quercétine.52-67

La leucotriène B4 détruit le cartilage des articulations. L'enzyme qui convertit l'acide arachidonique en leucotriène B4 dans l'organisme s'appelle la 5-LOX (5-lipoxygénase).68,69  Des méthodes sûres pour inhiber la 5-LOX et la production ultérieure de leucotriène B4 doivent être suivies d'un régime alimentaire pauvre en acide arachidonique et complétées par des nutriments comme la curcumine, le boswellia et l'huile de poisson. 70-83

Le facteur nucléaire kappaB déclenche la production de molécules inflammatoires systémiques qui attaquent les membranes des articulations. Le facteur nucléaire kappaB (NF-kB) peut être supprimé à l'aide d'extraits de plantes comme l'ail, le gingembre, la curcumine et la silymarine, ainsi que de concentrés d'huile de poisson et d'antioxydants.61-63, 84-91

Le vieillissement entraîne souvent une perte accélérée du cartilage des articulations protectrices. Les nutriments qui aident à reconstruire le cartilage incluent la glucosamine, la chondroïtine et le MSM (méthylsulfonylméthane).92-104 Il est peu probable que ces nutriments obtiennent des résultats complets si des facteurs inflammatoires chroniques continuent d’attaquer le cartilage des articulations.

Des recherches récentes suggèrent que la "sensibilité" au système immunitaire joue un rôle important dans l'arthrose105. L'hyperréactivité du système immunitaire (auto-immunité) joue depuis longtemps un rôle important dans la polyarthrite rhumatoïde106,107. Des recherches de pointe sur l'arthrose la plus répandue suggèrent que les cellules T "sensibilisées" attaquent le collagène des articulations et contribuent directement aux lésions articulaires.106-108

Le collagène de type II non dénaturé à faible dose (40 mg) aide à réguler la fonction immunitaire de sorte que les cellules T ne deviennent pas «sensibilisées» et n'attaquent pas le cartilage des articulations108-110.

L'acide hyaluronique est un composant majeur du tissu articulaire. Sa fonction naturelle est de lubrifier et d’amortir l’articulation contre les impacts répétés.111 Il est également impliqué dans la régénération du cartilage. L’un des effets notables de l’acide hyaluronique est d’inhiber une enzyme appelée matrice métalloprotéinase-13 qui dégrade le cartilage des articulations.112-114 L'acide hyaluronique n'absorbe pas bien par lui-même, mais lorsqu'il est dissous dans une solution riche en phospholipides115 telle que l'huile de krill, son absorption est améliorée.

Les cytokines inflammatoires telles que le facteur de nécrose tumorale alpha attaquent directement les muqueuses articulaires. L’huile de krill réduit l’infiltration de cytokines destructrices dans le revêtement des articulations.116, 117 L'astaxanthine réduit la production de cytokines inflammatoires.118-120

Pourquoi tant de personnes souffrant d'arthrite ne parviennent pas à trouver un soulagementLe dysfonctionnement mitochondrial interfère avec les processus de réparation juvéniles au niveau de l'articulation.121 Les nutriments qui protègent la fonction des mitochondries incluent l'acide lipoïque CoQ10,122-125, la carnitine 126-130, la 130-134 et la pyroloquinoléine quinone).

Les radicaux libres sont fortement impliqués dans la destruction conjointe. L'utilisation quotidienne d'antioxydants tels que l'acide lipoïque et l'astaxanthine procure une protection considérable.138-144

La prostaglandine E1 est une substance naturelle ressemblant à une hormone qui supprime l'inflammation. Il provient d'un acide gras appelé acide gamma-linolénique (GLA) que l'on obtient dans leur régime alimentaire ou par le biais de suppléments comme l'huile de bourrache ou l'huile d'onagre.145 Que l'AGL se convertisse en acide arachidonique pro-inflammatoire ou en prostaglandine E1 anti-inflammatoire est déterminé par une enzyme du corps régulée par les lignanes au sésame.146-151 Ceux qui obtiennent des lignanes au sésame dans leurs suppléments en bénéficient déjà, car le GLA obtenu à partir de sources alimentaires est plus susceptible de se convertir en prostaglandine E1. Ceux qui prennent des suppléments tels que l'huile de bourrache doivent s'assurer que l'huile de bourrache contient également au moins 10 mg de lignanes de sésame normalisés.
 Matériel utilisé avec la permission de Life Extension. Tous les droits sont réservés.

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Mots clés : Kurkumina, Kwas liponowy, Pqq, Resweratrol, Stawy, Zielona herbata
Publié dans: Acides gras oméga-3, Thé vert, Articulations, Acide lipoïque, Mitochondries, Resveratrol, Curcumine, PQQ

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