1. Home page
  2. Home
  3. Blog
  4. Acidi grassi omega-3
  5. Perché così tanti malati di artrite non riescono a trovare sollievo

Perché così tanti malati di artrite non riescono a trovare sollievo

9697 Views Posted on: 2016-03-17
Posted by: Ireneusz Adamczyk

Why So Many Arthritis Sufferers Fail to Find ReliefLa nostra società è stata programmata per credere che problemi medici complessi possano essere risolti con soluzioni semplici.

Chiunque abbia letto questo articolo ha probabilmente visto migliaia di spot televisivi che promuovono un sollievo immediato dal dolore da artrite assumendo la giusta marca di aspirina, ibuprofene, paracetamolo o naprossene.

Se un malato di artrite assume uno qualsiasi di questi antidolorifici su base costante (a dosi approvate dalla FDA), è probabile che incontri effetti collaterali pericolosi per la vita come insufficienza renale, insufficienza epatica o emorragia gastrica.1-8

Gli approcci naturali, d'altra parte, come l'olio di pesce e la curcumina forniscono numerosi benefici collaterali salvavita, oltre ad aiutare ad alleviare il disagio articolare cronico.9-40

L'industria farmaceutica si è concentrata sullo sviluppo di un solo intervento farmacologico alla volta per trattare una causa alla base dell'artrite. Non solo questa strategia non è riuscita ad affrontare i molti fattori legati all'età coinvolti nell'artrosi, ma ha portato a squilibri metabolici letali che si verificano nel corpo.

Quando i farmaci inibitori della COX-2 come Vioxx® e Bextra® furono approvati per la prima volta, Life Extension® avvertì che bloccando solo l'enzima COX-2 (e non anche COX-1 e 5-LOX), i consumatori di questi farmaci aumentavano il rischio di infarto e ictus. Mentre alla maggior parte dei nostri membri sono stati risparmiati questi effetti collaterali letali, decine di migliaia di americani sono morti prima che questi inibitori della COX-2 fossero ritirati.41

Ciò che nessuno ha fatto fino ad ora è amalgamare tutte le cause note dell'artrite in modo che i laici e i medici possano capire perché il sollievo a lungo termine richiede un approccio su più fronti.

La buona notizia per i membri Life Extension® è che utilizzano già molti modi naturali per migliorare la struttura e la funzione articolare che forniscono una notevole tregua dal disagio articolare. Le prossime due pagine forniscono una panoramica di dodici meccanismi sottostanti coinvolti nell'osteoartrosi e metodi sicuri per aggirarli.

Dodici cause correggibili di osteoartrite

Twelve Correctable Causes of OsteoarthritisCome tante malattie dell'invecchiamento, l'artrite non è normalmente causata da un singolo fattore. Invece, molteplici meccanismi cospirano per distruggere lentamente la cartilagine che riveste le nostre articolazioni. L'illustrazione seguente rivela le cause alla base dell'artrite e i semplici passaggi che puoi intraprendere per contrastarle.

L'eccesso di peso corporeo può portare all'artrite. Ciò accade non solo perché carichi meccanici più pesanti generano un maggiore stress fisico sul tessuto connettivo e sulle superfici articolari, ma anche dall'effetto che il grasso in eccesso ha nell'aumentare le molecole infiammatorie che attaccano e danneggiano la cartilagine articolare. La perdita di peso è un modo efficace per proteggere dallo stress articolare in eccesso che può contribuire all'artrite.42-46

Traumi fisici ad alto impatto possono danneggiare le articolazioni. Sebbene i benefici dell'esercizio non possano essere sottovalutati, esercizi ripetitivi e ad alto impatto come la corsa possono esporre le articolazioni (soprattutto nell'anca e nel ginocchio) a carichi meccanici elevati che possono contribuire a danneggiare le articolazioni nel tempo. Impegnarsi in esercizi che costruiscono la forza e la flessibilità muscolare senza traumi articolari ripetitivi può ridurre le complicanze dell'artrite.47-49

La prostaglandina E2 provoca dolore e infiammazione alle articolazioni. L'enzima che converte l'acido arachidonico in prostaglandina E2 nell'organismo è chiamato COX-2 (cicloossigenasi-2).50 I farmaci che inibiscono solo la COX-2 (come Vioxx® e Bextra®) aumentano il rischio di infarto perché creano effetti avversi sugli enzimi critici nelle cellule endoteliali vascolari che rivestono le pareti dei vasi sanguigni.51 I modi sicuri per inibire la COX-2 e la successiva produzione di prostaglandina E2 sono seguire una dieta a basso contenuto di acido arachidonico, assumere una compressa di aspirina a basso dosaggio (81 mg). ogni giorno e integra con sostanze nutritive come resveratrolo, estratto di tè verde, silimarina e quercetina.52-67

Il leucotriene B4 distrugge la cartilagine articolare. L'enzima che converte l'acido arachidonico in leucotriene B4 nel corpo è chiamato 5-LOX (5-lipossigenasi). e per integrare con sostanze nutritive come curcumina, boswellia e olio di pesce.70-83

Il fattore nucleare-kappaB accende la produzione di molecole infiammatorie sistemiche che attaccano i rivestimenti articolari. Il fattore nucleare-kappaB (NF-kB) può essere soppresso con estratti vegetali come aglio, zenzero, curcumina e silimarina, insieme a concentrati di olio di pesce e antiossidanti.61-63, 84-91

L'invecchiamento spesso provoca la perdita accelerata della cartilagine articolare protettiva. I nutrienti che aiutano a ricostruire la cartilagine includono glucosamina, condroitina e MSM (metilsulfonilmetano).92-104 È improbabile che questi nutrienti ottengano risultati completi se i fattori infiammatori cronici continuano ad attaccare la cartilagine articolare.

Recenti ricerche suggeriscono che la "sensibilità" del sistema immunitario svolga un ruolo importante nell'osteoartrite.105 È noto da tempo che l'iperreattività del sistema immunitario (autoimmunità) svolge un ruolo importante nell'artrite reumatoide.106,107 Ricerche all'avanguardia nell'osteoartrite più diffusa suggeriscono che i linfociti T "sensibilizzati" attaccano il collagene articolare e contribuiscono direttamente al danno articolare.106-108 Il collagene di tipo II non denaturato a basse dosi (40 mg) aiuta a regolare la funzione immunitaria in modo che i linfociti T non si "sensibilizzino" e attacchino l'articolazione cartilagine.108-110

L'acido ialuronico è un componente importante del tessuto articolare. La sua funzione naturale è quella di lubrificare e attutire l'articolazione da impatti ripetuti.111 È anche coinvolto nella rigenerazione della cartilagine. Un effetto notevole dell'acido ialuronico è quello di inibire un enzima chiamato metalloproteinasi-13 della matrice che degrada la cartilagine articolare.112-114 L'acido ialuronico non si assorbe bene da solo, ma quando viene sciolto in una soluzione ricca di fosfolipidi115 come l'olio di krill, il suo l'assorbimento è migliorato.

Le citochine infiammatorie come il fattore di necrosi tumorale-alfa attaccano direttamente i rivestimenti articolari. L'olio di krill riduce l'infiltrazione di citochine distruttive nei rivestimenti articolari.116,117 L'astaxantina riduce la produzione di citochine infiammatorie.118-120

La disfunzione mitocondriale interferisce con i processi di riparazione giovanile nell'articolazione.121 I nutrienti che proteggono la funzione dei mitocondri includono CoQ10,122-125 acido lipoico,126-130 carnitina,130-134 e PQQ (pirrolochinolina chinone).135-137Why So Many Arthritis Sufferers Fail to Find Relief

I radicali liberi sono fortemente coinvolti nella distruzione delle articolazioni. L'uso quotidiano di antiossidanti come l'acido lipoico e l'astaxantina offre una protezione considerevole.138-144

La prostaglandina E1 è una sostanza naturale simile a un ormone che sopprime l'infiammazione. Viene da un acido grasso chiamato acido gamma-linolenico (GLA) che si ottiene nella dieta o tramite integratori come l'olio di borragine o l'olio di enotera.145 È determinato se il GLA si converte in acido arachidonico pro-infiammatorio o prostaglandina antinfiammatoria E1 da un enzima nel corpo che è regolato dai lignani di sesamo.146-151 Coloro che ottengono lignani di sesamo nei loro integratori già beneficiano perché è più probabile che il GLA ottenuto da fonti alimentari si converta in prostaglandina E1. Coloro che assumono integratori come l'olio di borragine dovrebbero assicurarsi che l'olio di borragine contenga anche almeno 10 mg di lignani di sesamo standardizzati.

Materiale utilizzato con il permesso di Life Extension. Tutti i diritti riservati.

[1] Becker JC, Domschke W, Pohle T. Current approaches to prevent NSAID-induced gastropathy–COX selectivity and beyond. Br J Clin Pharmacol. 2004 Dec;58(6):587-600.

Bromer MQ, Black M. Acetaminophen hepatotoxicity. Clin Liver Dis. 2003 May;7(2):351–67.

Derby LE, Jick H. Acetaminophen and renal and bladder cancer. Epidemiology. 1996 Jul;7(4):358–62.

Zaffanello M, Brugnara M, Angeli S, Cuzzolin L. Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report. Acta Paediatr. 2009 May;98(5):903-5.

Lee WM, Seremba E. Etiologies of acute liver failure. Curr Opin Crit Care. 2008 Apr;14(2):198-201.

Schoenfeld P, Kimmey MB, Scheiman J, Bjorkman D, Laine L. Review article: nonsteroidal anti-inflammatory drug-associated gastrointestinal complications–guidelines for prevention and treatment. Aliment Pharmacol Ther. 1999 Oct;13(10):1273-85.

Whelton A, Hamilton CW. Nonsteroidal anti-inflammatory drugs: Effects on kidney function. J Clin Pharmacol. 1991 Jul;31(7):588–98.

Yamamoto T. Yamamoto T, Kuyama Y. Treatment and prevention of NSAIDs-induced gastrointestinal injury–the role of gastroenterologist. Nihon Rinsho. 2011 Jun;69(6):1072-4.

[2] Limtrakul P. Curcumin as chemosensitizer. Adv Exp Med Biol. 2007;595:269-300.

Lin JK. Molecular targets of curcumin. Adv Exp Med Biol. 2007;595:227-43.

Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007;595:127-48.

Bright JJ. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007;595:425-51.

Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol. 2007;595:359-77.

Thangapazham RL, Sharma A, Maheshwari RK. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol. 2007;595:343-57.

Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Ann NY Acad Sci. 2005 Nov;1056:206-17.

Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105-25.

Jagetia GC, Aggarwal BB. „Spicing up” of the immune system by curcumin. J Clin Immunol. 2007 Jan;27(1):19-35.

Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci. 2006 Mar 27;78(18):2081-7.

Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res. 1980 Apr;71:632-4.

Albert CM, Hennekens CH, O’Donnell CJ, et al. Fish consumption and risk of sudden cardiac death. JAMA. 1998 Jan 7;279(1):23-8.

Leaf A, Albert CM, Josephson M, et al. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation. 2005 Nov 1;112(18):2762–8.

Christensen JH, Riahi S, Schmidt EB, et al. n-3 fatty acids and ventricular arrhythmias in patients with ischaemic heart disease and implantable cardioverter defibrillators. Europace. 2005 Jul;7(4):338–44.

Freeman MP, Hibbeln JR, Silver M, et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. Menopause. 2011 Mar;18(3):279-84.

Belin RJ, Greenland P, Martin L, et al. Fish intake and the risk of incident heart failure: the Women’s Health Initiative. Circ Heart Fail. 2011 Jul 1;4(4):404-13.

Calo L, Bianconi L, Colivichi F, et al. N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol. 2005 May 17;45(10):1723-8.

Connor SL, Connor WE. Are fish oils beneficial in the prevention and treatment of coronary artery disease? Am J Clin Nutr. 1997 Oct;66(4 Suppl):1020S-31S.

Abeywardena MY, Head RJ. Longchain n-3 polyunsaturated fatty acids and blood vessel function. Cardiovasc Res. 2001 Dec;52(3):361-71.

Thies F, Garry JM, Yaqoob P, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomized controlled trial. Lancet. 2003 Feb 8;361(9356):477–85.

Stammers T, Sibblad B, Freeling P. Fish oil in osteoarthritis. Lancet. 1989. Aug 26;2(8661):503.

Curtis CL, Rees SG, Little CB, et al. Pathological indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. Arthritis Rheum. 2002 Jun;46(6):1544-53.

Curtis CL, Rees SG, Cramp J, et al. Effects of n-3 fatty acids on cartilage metabolism. Proc Nutr Soc. 2002 Aug;61(3):381-9.

Hagfors L, Nilsson I, Skoldstam L, Johansson G. Fat intake and composition of fatty acids in serum phospholipids in a randomized, controlled, Mediterranean dietary intervention study on patients with rheumatoid arthritis. Nutr Metab (Lond). 2005 Oct 10;2:26.

Volker D, Fitzgerald P, Major G, Gang M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol. 2000 Oct;27(10):2343-6.

James MJ, Cleland LG. Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum. 1997 Oct;27(2):85-97.

Kremer JM. n-3 fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr. 2000 Jan;71(1 Suppl):349S-51S.

James MJ, Proudman SM, Cleland LG. Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2003 Jun;68(6):399-405.

Fortin PR, Lew RA, Liang MH, et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J Clin Epidemiol. 1995 Nov;48(11):1379-90.

Rhodes LE, Shahbakhti H, Azurdia RM, et al. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers. Carcinogenesis. 2003 May;24(5):919-25.

Maheo K, Vibet S, Steghens JP, et al. Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation. Free Radic Biol Med. 2005 Sep 15;39(6):742-51.

Menendez JA, Lupu R, Colomer R, et al. Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. Eur J Cancer Prev. 2005 Jun;14(3):263-70.

[3] Topol EJ. Failing the public health—rofecoxib, Merck, and the FDA. N Engl J Med. 2004 Oct 21;351(17):1707-9.

[4] Reynolds SL, McIlvane JM. The impact of obesity and arthritis on active life expectancy in older Americans. Obesity (Silver Spring). 2009 Feb;17(2):363-9.

Busija L, Buchbinder R, Osborne RH. Quantifying the impact of transient joint symptoms, chronic joint symptoms, and arthritis: a population-based approach. Arthritis Rheum. 2009 Oct 15;61(10):1312-21.

Chaganti RK, Lane NE. Risk factors for incident osteoarthritis of the hip and knee. Curr Rev Musculoskelet Med. 2011 Aug 2.

Centers for Disease Control and Prevention (CDC). Prevalence of obesity among adults with arthritis — United States, 2003–2009. MMWR Morb Mortal Wkly Rep.2011 Apr 29;60(16):509-13.

Muthuri SG, Hui M, Doherty M, Zhang W. What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies. Arthritis Care Res (Hoboken). 2011 Jul;63(7):982-90.

[5] Mann G, Hetsroni I, Mei-Dan O. Continuous physical activity and the incidence of degenerative changes occurring in the lower limbs. Harefuah. 2008 Apr;147(4):311-3, 374.

Buckwalter JA, Martin JA. Sports and osteoarthritis. Curr Opin Rheumatol. 2004 Sep;16(5):634-9.

Buckwalter JA. Sports, joint injury, and posttraumatic osteoarthritis. J Orthop Sports Phys Ther. 2003 Oct;33(10):578-88.

[6] Weinberg JB. Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. Immunol Res. 2000;22(2-3):319-41.

[7] Mitchell JA, Lucas R, Vojnovic I, Hasan K, Pepper JR, Warner TD. Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events. FASEB J. 2006 Dec;20(14):2468-75.

[8] Adam O, Beringer C, Kless T, et al. Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. Rheumatol Int. 2003 Jan;23(1):27-36.

Elkhouli AM. The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study). J Periodontal Res. 2011 Apr;46(2):261-8.

Feldman M, Jialal I, Devaraj S, Cryer B. Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. J Am Coll Cardiol. 2001 Jun15;37(8):2036-41.

Morris T, Stables M, Hobbs A, et al. Effects of low-dose aspirin on acute inflammatory responses in humans. J Immunol. 2009 Aug 1;183(3):2089-96.

Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis ResTher. 2009;11(6):R165.

Shakibaei M, Csaki C, Nebrich S, Mobasheri A. Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem Pharmacol. 2008 Dec 1;76(11):1426-39.

Csaki C, Keshishzadeh N, Fischer K, Shakibaei M. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem Pharmacol. 2008 Feb 1;75(3):677-87.

Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol Exp Ther. 2004 Feb;308(2):767-73.

Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med. 2002 Oct 15;33(8):1097-105.

Hussain SA, Jassim NA, Numan IT, Al-Khalifa II, Abdullah TA. Anti-inflammatory activity of silymarin in patients with knee osteoarthritis. A comparative study with piroxicam and meloxicam. Saudi Med J. 2009 Jan;30(1):98-103.

Khanna D, Sethi G, Ahn KS, et al. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007 Jun;7(3):344-51.

Gupta OP, Sing S, Bani S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000 Mar;7(1):21-4.

Sato M, Miyazaki T, Kambe F, Maeda K, Seo H. Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1expression by tumor necrosis factor-alpha in cultured human synovial cells. J Rheumatol. 1997 Sep;24(9):1680-4.

Jackson JK, Higo T, Hunter WL, Burt HM. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm Res.2006 Apr;55(4):168-75.

Mamani-Matsuda M, Kauss T, Al-Kharrat A, et al. Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol. 2006 Nov 15;72(10):1304-10.

Yu ES, Min HJ, An SY, Won HY, Hong JH, Hwang ES. Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells. Biochem Pharmacol. 2008 Jul 1;76(1):70-8.

Martel-Pelletier J, Mineau F, Fahmi H, et al. Regulation of the expression of 5-lipoxyge

[9] Martel-Pelletier J, Mineau F, Fahmi H, et al. Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids. Arthritis Rheum. 2004 Dec;50(12):3925-33.

Sampson AP. FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.

[10] Swamy MV, Citineni B, Patlolla JM, Mohammed A, Zhang Y, Rao CV. Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. Nutr Cancer. 2008;60 Suppl 1:81-9.

Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009 Feb;30(2):85-94.

Saw CL, Huang Y, Kong AN. Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid. Biochem Pharmacol. 2010 Feb 1;79(3):421-30.

Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. 2011 Mar 1;12(3):332-47.

Hong J, Bose M, Ju J, et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 2004 Sep;25(9):1671-9.

Chopra A, Lavin P, Patwardhan B, Chitre D. A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2004 Oct;10(5):236-45.

Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.

Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):R85.

Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010 Nov 1;7(6):366-77.

Curtis CL, Rees SG, Little CB, e al. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. Arthritis Rheum. 2002 Jun;46(6):1544-53. Retraction in: Caterson B. Arthritis Rheum. 2006 Sep;54(9):2933.

Cleland LG, French JK, Betts WH, Murphy GA, Elliott MJ. Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. J Rheumatol. 1988 Oct;15(10):1471-5.

James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000 Jan;71(1 Suppl):343S-8S.

Calder PC. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‚Nutrition and autoimmune disease’ PUFA, inflammatory processes and rheumatoid arthritis. Proc Nutr Soc. 2008 Nov;67(4):409-18.

Kalogeropoulos N, Panagiotakos DB, Pitsavos C, et al. Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults. Clin Chim Acta. 2010 Apr 2;411(7-8):584-91.

[11] Hussain SA, Jassim NA, Numan IT, Al-Khalifa II, Abdullah TA. Anti-inflammatory activity of silymarin in patients with knee osteoarthritis. A comparative study with piroxicam and meloxicam. Saudi Med J. 2009 Jan;30(1):98-103.

Khanna D, Sethi G, Ahn KS, et al. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007 Jun;7(3):344-51.

Gupta OP, Sing S, Bani S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000 Mar;7(1):21-4.

Ban JO, Oh JH, Kim TM, et al. Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB. Arthritis Res Ther. 2009;11(5):R145.

Zhao Y, Joshi-Barve S, Barve S, Chen LH. Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J Am Coll Nutr. 2004 Feb;23(1):71-8.

Rahman MM, Bhattacharya A, Fernandes G. Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. J Cell Physiol. 2008 Jan;214(1):201-9.

Kim MK, Chung SW, Kim DH, et al. Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. Exp Gerontol. 2010 Jun;45(6):419-26.

Grzanna R, Lindmark L, Frondoza CG. Ginger–an herbal medicinal product with broad anti-inflammatory actions. J ed Food. 2005 Summer;8(2):125-32.

Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004 Dec;1030:434-41.

Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Curcumin mediated suppression of nuclear factor-B promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther.2010;12(4):R127.

Wilkins R, Tucci M, Benghuzzi H. Role of plant-derived antioxidants on NF-kb expression in LPS-stimulated macrophages – biomed 2011. Biomed Sci Instrum. 2011;47:222-7.

[12] . Brandt KD, Mazzuca SA, Katz BP. Methodology and statistical analysis in the Glucosamine/Chondroitin Arthritis Intervention Trial: comment on the article by Sawitzke et al. Arthritis Rheum. 2009 Nov;60(11):3514-5; author reply 3515-6.

Brien S, Prescott P, Bashir N, Lewith H, Lewith G. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2008 Nov;16(11):1277-88.

Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62.

Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.

Jerosch J. Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially omega-3 fatty acids. Int J Rheumatol. 2011;2011:969012.

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006 Mar;14(3):286-94.

Leeb BF, Schweitzer H, Montag K, Smolen JS. A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis. J Rheumatol 2000 Jan;27(1):205-11.

McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000 Mar 15;283(11):1469-75.

Nakamura H, Masuko K, Yudoh K, Kato T, Kamada T, Kawahara T. Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int. 2007 Jan;27(3):213-8.

Omata T, Itokazu Y, Inoue N, Segawa Y. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung 2000 Feb;50(2):148-53.

Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998 May;48 (5):469-74.

Sawitzke AD, Shi H, Finco MF, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum. 2008 Oct;58(10):3183-91.

Kamarul T, Ab-Rahim S, Tumin M, Selvaratnam L, Ahmad TS. A preliminary study of the effects of glucosamine sulphate and chondroitin sulphate on surgically treated and untreated focal cartilage damage. Eur Cell Mater. 2011;21:259-71; discussion 70-1.

[13] Bagchi D, Misner B, Bagchi M, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.

Trentham DE, Dynesius-Trentham RA, Orav EJ, et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24;261(5129):1727-30.

[14] Gupta RC, Canerdy TD, Skaggs P, et al. Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses. J Vet Pharmacol Ther. 2009 Dec;32(6):577-84.

D’Altilio M, Peal A, Alvey M, et al. Therapeutic efficacy and safety of undenatured type II collagen singly or in combination with glucosamine and chondroitin in arthritic dogs. Toxicol Mech Methods. 2007;17(4):189-96.

Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312-21.

[15] Gupta RC, Canerdy TD, Skaggs P, et al. Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses. J Vet Pharmacol Ther. 2009 Dec;32(6):577-84.

D’Altilio M, Peal A, Alvey M, et al. Therapeutic efficacy and safety of undenatured type II collagen singly or in combination with glucosamine and chondroitin in arthritic dogs. Toxicol Mech Methods. 2007;17(4):189-96.

Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312-21.

[16] Greene GW, Banquy X, Lee DW, Lowrey DD, Yu J, Israelachvili JN. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5255-9.

[17] Li NG, Shi ZH, Tang YP, et al. New hope for the treatment of osteoarthritis through selective inhibition of MMP-. Curr Med Chem. 2011;18(7):977-1001.

Campo GM, Avenoso A, Nastasi G, et al. Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression. Biochim Biophys Acta. 2011 Sep;1812(9):1170-81.

Bikadi Z, Hazai E, Zsila F, Lockwood SF. Molecular modeling of non-covalent binding of homochiral (3S,3’S)-astaxanthin to matrix metalloproteinase-13 (MMP-13). Bioorg Med Chem. 2006 Aug 15;14(16):5451-8.

[18] Huang SL, Ling PX, Zhang TM. Oral absorption of hyaluronic acid and phospholipids complexes in rats. World J Gastroenterol. 2007 Feb 14;13(6):945-9.

[19] Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr. 2007 Feb;26(1):39-48.

Valensa. FlexPro MD Clinical Trial Overview and Results. (Data on File.) 2011.

[20] Kim YJ, Kim YA, Yokozawa T. Protection against oxidative stress, inflammation, and apoptosis of high-glucose-exposed proximal tubular epithelial cells by astaxanthin. J Agric Food Chem. 2009 Oct 14;57(19):8793-7.

Choi SK, Park YS, Choi DK, Chang HI. Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells. J Microbiol Biotechnol. 2008 Dec;18(12):1990-6.

Schmidt N, Pautz A, Art J, et al. Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochem Pharmacol. 2010 Mar 1;79(5):722-32.

[21] Grishko VI, Ho R, Wilson GL, Pearsall AW 4th. Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes. Osteoarthritis Cartilage. 2009 Jan;17(1):107-13.

[22] Glover EI, Martin J, Maher A, Thornhill RE, Moran GR, Tarnopolsky MA. A randomized trial of coenzyme Q10 in mitochondrial disorders. Muscle Nerve. 2010 Nov;42(5):739-48.

Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7.

Moreira PI, Santos MS, Sena C, Nunes E, Seiça R, Oliveira CR. CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats. Exp Neurol. 2005 Nov;196(1):112-9.

Haas RH. The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. Mitochondrion. 2007 Jun;Suppl:S136-45.

[23] Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr. 2011 Jan;48(1):26-32.

Aliev G, Li Y, Palacios HH, Obrenovich ME. Oxidative stress inducedmitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases. Recent Pat Cardiovasc Drug Discov. 2011 Sep 1;6(3):222-41.

Tabassum H, Parvez S, Pasha ST, Banerjee BD, Raisuddin S. Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria. Food Chem Toxicol. 2010 Jul;48(7):1973-9.

Monette JS, Gómez LA, Moreau RF, et al. (R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria. Pharmacol Res. 2011 Jan;63(1):23-9.

Sethumadhavan S, Chinnakannu P. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. Biogerontology. 2006 Apr;7(2):101-9.

[24] Sethumadhavan S, Chinnakannu P. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. Biogerontology. 2006 Apr;7(2):101-9.

Oyanagi E, Yano H, Uchida M, Utsumi K, Sasaki J. Protective action of l-carnitine on cardiac mitochondrial function and structure against fatty acid stress. Biochem Biophys Res Commun. 2011 Aug 19;412(1):61-7.

Ye J, Li J, Yu Y, Wei Q, Deng W, Yu L. L-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regul Pept. 2010 Apr 9;161(1-3):58-66.

Inazu M, Matsumiya T. Physiological functions of carnitine and carnitine transporters in the central nervous system. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008 Jun;28(3):113-20.

Chang B, Nishikawa M, Nishiguchi S, Inoue M. L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int J Cancer. 2005 Feb 20;113(5):719-29.

[25] Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52.

Rucker R, Chowanadisai W, Nakano M. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009 Sep;14(3):268-77.

Tao R, Karliner JS, Simonis U, et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 2007 Nov 16;363(2):257-62.

[26] Yuan JP, Peng J, Yin K, Wang JH. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011 Jan;55(1):150-65.

Bloomer RJ. The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. Sports Med. 2007;37(6):519-32.

Karppi J, Rissanen TH, Nyyssönen K, et al. Effects of astaxanthin supplementation on lipid peroxidation. Int J Vitam Nutr Res. 2007 Jan;77(1):3-11.

Nakagawa K, Kiko T, Miyazawa T, et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Br J Nutr. 2011 Jun;105(11):1563-71.

Ansar H, Mazloom Z, Kazemi F, Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J. 2011 Jun;32(6):584-8.

Zhang Y, Han P, Wu N, et al. Amelioration of lipid abnormalities by -lipoic acid through antioxidative and anti-inflammatory effects. Obesity (Silver Spring). 2011 Aug;19(8):1647-53.

Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski K, Stefaniak T, Dziubek W. Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol. 2009 Jun;60(2):139-43.

[27] Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr. 1998 Sep;128(9):1411-4.

[28] Chavali SR, Zhong WW, Forse RA. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice.Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91.

Gu JY, Wakizono Y, Tsujita A, et al. Effects of sesamin and alpha-tocopherol, individually or in combination, on the polyunsaturated fatty acid metabolism, chemical mediator production, and immunoglobulin levels in Sprague-Dawley rats. Biosci Biotechnol Biochem. 1995 Dec;59(12):2198-202.

Fujiyama-Fujiwara Y, Umeda-Sawada R, Kuzuyama M, Igarashi O. Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. J Nutr Sci Vitaminol (Tokyo). 1995 Apr;41(2):217-25.

Shimizu S, Akimoto K, Shinmen Y, Kawashima H, Sugano M, Yamada H. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis. Lipids. 1991 Jul;26(7):512-6.

Umeda-Sawada R, Ogawa M, Igarashi O. The metabolism and n-6/n-3 ratio ofessential fatty acids in rats: effect of dietary arachidonic acid and a mixtureof sesame lignans (sesamin and episesamin). Lipids. 1998 Jun;33(6):567-72.

Akimoto K, Kitagawa Y, Akamatsu T, et al. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab. 1993;37(4):218-24.

Questo articolo è stato interessante per te?
Posted in: Acidi grassi omega-3, Tè verde, Giunti, Acido lipoico, Mitocondri, Resveratrolo, Curcumina, PQQ

Articoli Correlati