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Perché così tanti malati di artrite non riescono a trovare sollievo

8941 Views Posted on: 2016-03-17
Posted by: Ireneusz Adamczyk

Why So Many Arthritis Sufferers Fail to Find ReliefLa nostra società è stata programmata per credere che problemi medici complessi possano essere risolti con soluzioni semplici.

Chiunque abbia letto questo articolo ha probabilmente visto migliaia di spot televisivi che promuovono un sollievo immediato dal dolore da artrite assumendo la giusta marca di aspirina, ibuprofene, paracetamolo o naprossene.

Se un malato di artrite assume uno qualsiasi di questi antidolorifici su base costante (a dosi approvate dalla FDA), è probabile che incontri effetti collaterali pericolosi per la vita come insufficienza renale, insufficienza epatica o emorragia gastrica.1-8

Gli approcci naturali, d'altra parte, come l'olio di pesce e la curcumina forniscono numerosi benefici collaterali salvavita, oltre ad aiutare ad alleviare il disagio articolare cronico.9-40

L'industria farmaceutica si è concentrata sullo sviluppo di un solo intervento farmacologico alla volta per trattare una causa alla base dell'artrite. Non solo questa strategia non è riuscita ad affrontare i molti fattori legati all'età coinvolti nell'artrosi, ma ha portato a squilibri metabolici letali che si verificano nel corpo.

Quando i farmaci inibitori della COX-2 come Vioxx® e Bextra® furono approvati per la prima volta, Life Extension® avvertì che bloccando solo l'enzima COX-2 (e non anche COX-1 e 5-LOX), i consumatori di questi farmaci aumentavano il rischio di infarto e ictus. Mentre alla maggior parte dei nostri membri sono stati risparmiati questi effetti collaterali letali, decine di migliaia di americani sono morti prima che questi inibitori della COX-2 fossero ritirati.41

Ciò che nessuno ha fatto fino ad ora è amalgamare tutte le cause note dell'artrite in modo che i laici e i medici possano capire perché il sollievo a lungo termine richiede un approccio su più fronti.

La buona notizia per i membri Life Extension® è che utilizzano già molti modi naturali per migliorare la struttura e la funzione articolare che forniscono una notevole tregua dal disagio articolare. Le prossime due pagine forniscono una panoramica di dodici meccanismi sottostanti coinvolti nell'osteoartrosi e metodi sicuri per aggirarli.

Dodici cause correggibili di osteoartrite

Twelve Correctable Causes of OsteoarthritisCome tante malattie dell'invecchiamento, l'artrite non è normalmente causata da un singolo fattore. Invece, molteplici meccanismi cospirano per distruggere lentamente la cartilagine che riveste le nostre articolazioni. L'illustrazione seguente rivela le cause alla base dell'artrite e i semplici passaggi che puoi intraprendere per contrastarle.

L'eccesso di peso corporeo può portare all'artrite. Ciò accade non solo perché carichi meccanici più pesanti generano un maggiore stress fisico sul tessuto connettivo e sulle superfici articolari, ma anche dall'effetto che il grasso in eccesso ha nell'aumentare le molecole infiammatorie che attaccano e danneggiano la cartilagine articolare. La perdita di peso è un modo efficace per proteggere dallo stress articolare in eccesso che può contribuire all'artrite.42-46

Traumi fisici ad alto impatto possono danneggiare le articolazioni. Sebbene i benefici dell'esercizio non possano essere sottovalutati, esercizi ripetitivi e ad alto impatto come la corsa possono esporre le articolazioni (soprattutto nell'anca e nel ginocchio) a carichi meccanici elevati che possono contribuire a danneggiare le articolazioni nel tempo. Impegnarsi in esercizi che costruiscono la forza e la flessibilità muscolare senza traumi articolari ripetitivi può ridurre le complicanze dell'artrite.47-49

La prostaglandina E2 provoca dolore e infiammazione alle articolazioni. L'enzima che converte l'acido arachidonico in prostaglandina E2 nell'organismo è chiamato COX-2 (cicloossigenasi-2).50 I farmaci che inibiscono solo la COX-2 (come Vioxx® e Bextra®) aumentano il rischio di infarto perché creano effetti avversi sugli enzimi critici nelle cellule endoteliali vascolari che rivestono le pareti dei vasi sanguigni.51 I modi sicuri per inibire la COX-2 e la successiva produzione di prostaglandina E2 sono seguire una dieta a basso contenuto di acido arachidonico, assumere una compressa di aspirina a basso dosaggio (81 mg). ogni giorno e integra con sostanze nutritive come resveratrolo, estratto di tè verde, silimarina e quercetina.52-67

Il leucotriene B4 distrugge la cartilagine articolare. L'enzima che converte l'acido arachidonico in leucotriene B4 nel corpo è chiamato 5-LOX (5-lipossigenasi). e per integrare con sostanze nutritive come curcumina, boswellia e olio di pesce.70-83

Il fattore nucleare-kappaB accende la produzione di molecole infiammatorie sistemiche che attaccano i rivestimenti articolari. Il fattore nucleare-kappaB (NF-kB) può essere soppresso con estratti vegetali come aglio, zenzero, curcumina e silimarina, insieme a concentrati di olio di pesce e antiossidanti.61-63, 84-91

L'invecchiamento spesso provoca la perdita accelerata della cartilagine articolare protettiva. I nutrienti che aiutano a ricostruire la cartilagine includono glucosamina, condroitina e MSM (metilsulfonilmetano).92-104 È improbabile che questi nutrienti ottengano risultati completi se i fattori infiammatori cronici continuano ad attaccare la cartilagine articolare.

Recenti ricerche suggeriscono che la "sensibilità" del sistema immunitario svolga un ruolo importante nell'osteoartrite.105 È noto da tempo che l'iperreattività del sistema immunitario (autoimmunità) svolge un ruolo importante nell'artrite reumatoide.106,107 Ricerche all'avanguardia nell'osteoartrite più diffusa suggeriscono che i linfociti T "sensibilizzati" attaccano il collagene articolare e contribuiscono direttamente al danno articolare.106-108 Il collagene di tipo II non denaturato a basse dosi (40 mg) aiuta a regolare la funzione immunitaria in modo che i linfociti T non si "sensibilizzino" e attacchino l'articolazione cartilagine.108-110

L'acido ialuronico è un componente importante del tessuto articolare. La sua funzione naturale è quella di lubrificare e attutire l'articolazione da impatti ripetuti.111 È anche coinvolto nella rigenerazione della cartilagine. Un effetto notevole dell'acido ialuronico è quello di inibire un enzima chiamato metalloproteinasi-13 della matrice che degrada la cartilagine articolare.112-114 L'acido ialuronico non si assorbe bene da solo, ma quando viene sciolto in una soluzione ricca di fosfolipidi115 come l'olio di krill, il suo l'assorbimento è migliorato.

Le citochine infiammatorie come il fattore di necrosi tumorale-alfa attaccano direttamente i rivestimenti articolari. L'olio di krill riduce l'infiltrazione di citochine distruttive nei rivestimenti articolari.116,117 L'astaxantina riduce la produzione di citochine infiammatorie.118-120

La disfunzione mitocondriale interferisce con i processi di riparazione giovanile nell'articolazione.121 I nutrienti che proteggono la funzione dei mitocondri includono CoQ10,122-125 acido lipoico,126-130 carnitina,130-134 e PQQ (pirrolochinolina chinone).135-137Why So Many Arthritis Sufferers Fail to Find Relief

I radicali liberi sono fortemente coinvolti nella distruzione delle articolazioni. L'uso quotidiano di antiossidanti come l'acido lipoico e l'astaxantina offre una protezione considerevole.138-144

La prostaglandina E1 è una sostanza naturale simile a un ormone che sopprime l'infiammazione. Viene da un acido grasso chiamato acido gamma-linolenico (GLA) che si ottiene nella dieta o tramite integratori come l'olio di borragine o l'olio di enotera.145 È determinato se il GLA si converte in acido arachidonico pro-infiammatorio o prostaglandina antinfiammatoria E1 da un enzima nel corpo che è regolato dai lignani di sesamo.146-151 Coloro che ottengono lignani di sesamo nei loro integratori già beneficiano perché è più probabile che il GLA ottenuto da fonti alimentari si converta in prostaglandina E1. Coloro che assumono integratori come l'olio di borragine dovrebbero assicurarsi che l'olio di borragine contenga anche almeno 10 mg di lignani di sesamo standardizzati.

Materiale utilizzato con il permesso di Life Extension. Tutti i diritti riservati.

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